Roles of factor XI, platelets and tissue factor-initiated blood coagulation
نویسندگان
چکیده
منابع مشابه
Structural biology of factor VIIa/tissue factor initiated coagulation.
Factor VII (FVII) consists of an N-terminal gamma-carboxyglutamic acid domain followed by two epidermal growth factor-like (EGF1 and EGF2) domains and the C-terminal protease domain. Activation of FVII results in a two-chain FVIIa molecule consisting of a light chain (Gla-EGF1-EGF2 domains) and a heavy chain (protease domain) held together by a single disulfide bond. During coagulation, the com...
متن کاملFactor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available.
OBJECTIVE Feedback activation of factor XI by thrombin is a likely alternative for tissue factor-dependent propagation of thrombus formation. However, the hypothesis that thrombin can initiate and propagate its formation in a factor XI-dependent and platelet-dependent manner has not been tested in a plasma milieu. METHODS AND RESULTS We investigated thrombin generation in recalcified platelet...
متن کاملCharacterization of the Human Blood Coagulation Factor XI 1 Gene
A human genomic phage library was screened using a human factor XI1 cDNA as a hybridization probe. Two overlapping phage clones were isolated which contain the entire human factor XI1 gene. DNA sequence and restriction enzyme analysis of the clones indicate that the gene is approximately 12 kilobase pairs in size and is comprised of 13 introns and 14 exons. Exons 3-14 are contained in a genomic...
متن کاملFactor XI-dependence of surface- and tissue factor-initiated thrombus propagation in primates.
Thrombin, generated through activation of factor XI (FXI) and/or tissue factor (TF)-factor VIIa, is essential for thrombosis and hemostasis. We investigated the role of FXI-dependent thrombus propagation under arterial flow conditions producing rapid thrombus growth that, after the initiation phase, could limit the availability of TF at the blood/thrombus interface. Thrombosis was initiated by ...
متن کاملIntravascular tissue factor initiates coagulation via circulating microvesicles and platelets.
Although tissue factor (TF), the principial initiator of physiological coagulation and pathological thrombosis, has recently been proposed to be present in human blood, the functional significance and location of the intravascular TF is unknown. In the plasma portion of blood, we found TF to be mainly associated with circulating microvesicles. By cell sorting with the specific marker CD42b, pla...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2003
ISSN: 1538-7933,1538-7836
DOI: 10.1046/j.1538-7836.2003.00460.x